Molecular Formula | C25H33N7O2 |
Molar Mass | 463.58 |
Density | 1.31±0.1 g/cm3(Predicted) |
pKa | 12.70±0.46(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | UNC2881 inhibits Mer kinase activity at an IC50 of 22 nM in 697 B- ALL cells and inhibits collagen-stimulated platelet aggregation. UNC2881 inhibits Mer kinase activity at an IC50 of 22 nM in 697 B- ALL cells and inhibits collagen-stimulated platelet aggregation. |
In vivo study | In mice, UNC2881 had high total clearance (94.5/min/kg) and oral bioavailability of 14%. In Mice, UNC2881 had high total clearance (94.5/min/kg) and oral bioavailability of 14%. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.157 ml | 10.786 ml | 21.571 ml |
5 mM | 0.431 ml | 2.157 ml | 4.314 ml |
10 mM | 0.216 ml | 1.079 ml | 2.157 ml |
5 mM | 0.043 ml | 0.216 ml | 0.431 ml |